Endocrine Abstracts

Behavioural restrictions observed following Radioiodine therapy(RAI) administered for management of hyperthyroidism are becoming more stringent. Over the last two years we have administered a fixed 400 MBq RAI dose after performing a 24-hour RAI uptake test with a view to reducing post RAI restrictions e.g. for patients with a 50% uptake, restrictions applicable to 200 MBq were advised. The aim or our study was to compare the restrictions as advised by this method with what wo...

Central treatment with ghrelin increases body weight and fat accumulation. Here we explore the pharmacological effect of a combined central (ICV) infusion of ghrelin (0.3 nmol/day) and a recently developed ghrelin receptor (GHS-R1A) antagonist (JMV2959, 100 nmol/day) on food intake and body composition. The effect of ghrelin infusion for 14 days to increase body weight (20.7±0.9% vs 34.3±3.1%, saline vs ghrelin, P<0.001) was blocked by co-infusion with JMV...

Introduction and Aims: Graves’ disease (GD) is mediated by thyroid stimulating antibodies (TSAbs) to the TSH receptor (TSHR). Treatments for GD have remained unchanged for more than 40 years with less than 50% of patients achieving long term remission with medical therapy. Experimental animal models have been described which facilitate understanding of disease mechanisms and permit studies of novel immunotherapeutic interventions. However studies aiming to perturb the Th1...

Background: TQ Formula (TQ, C10H12O2), is an oral formulation, derived from the black seed (Nigella sativa, Ranunculaceae family), and has anti-oxidant, anti-angiogenic effects. TQ Formula has been shown to induce significant immune modulatory effects in a recently published Covid-19 study. Previous studies reported blackseed’s apoptotic and anti-proliferative effects of its components on multiple cancer types, including colon, breast and ovarian adenocarcinoma. Our preli...

Introduction: Left ventricular hypertrophy (LVH) is associated with increased morbidity and mortality. LVH defined by ECG (ECG-LVH) has been evaluated using standard voltage criteria by Sokolow and Lyon (SL-LVH) and more recently using the Cornell product criteria (CP-LVH). Evaluation of CP-LVH is beneficial in hypertensive patients: however, in patients with primary aldosteronism (PA) whose incidence of cardiovascular events is higher than essential hypertension (EHT), there ...

Introduction: Patients with acromegaly have an increased risk of colorectal cancer and pre-malignant adenomatous polyps; however the frequency of colonoscopic screening remains unclear.Aims: To determine optimum frequency for repeated colonoscopy of acromegalic patients.Methods: Since 1992, 254 patients (mean age 56.6 years) at our centre have undergone at least one fibre-optic colonoscopic surveillance; 156, 60 and 15 patients hav...

Differentiating aldosterone-producing adenomas (APA) from bilateral adrenal hyperplasia (BAH) as a cause of Conn’s syndrome (CS) is crucial for appropriate management. We have prospectively evaluated the relative contributions of PST, adrenal imaging by Computed Tomography (CT) and AVS in the differential diagnosis of CS.We investigated 25 consecutive patients with CS referred to our unit with an identical protocol. Every patient underwent PST, CT a...

The preparation of Sandostatin LAR® injections using a 2 ml ampoule of vehicle solution may be associated with some technical difficulties of administration, with adverse consequences for patients. The development of a 2.5 ml prefilled syringe may alleviate some of these problems. We have compared these two methods of Sandostatin LAR® administration in 17 patients with acromegaly and 5 patients with neuro-endocrine tumours, (6 drug naïve, 1...

Background: The role of surgical cytoreduction for metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is considered an area of debate due to lack of prospective data. While retrospective and single institution analyses demonstrated higher survival rates associated with surgical cytoreduction, there was no comparison with systemic therapies alone in these studies. The aim of this analysis of the National Cancer Database (NCDB) was to evaluate the survival benefi...

Introduction: We recently reported a high prevalence of |TgAb in sera from healthy Sri Lankan subjects. To characterise these further we have studied the reactions of these Abs with Tg in a competitive ELISA with a panel of 10 Tg monoclonal Abs (TgMabs). This is compared to a similar UK population of healthy subjects and AITD patients.Methods: The sera, all from females, comprised: 1. Healthy SL schoolgirls with high TgAb (HSL; n=33) 2. Healthy SL Tamil...